Table 5 The structures of PROTAC molecules targeting cancer metastasis. (red: POI ligand; yellow: E3 ligand)
From: Proteolysis-targeting chimeras (PROTACs) in cancer therapy
Target | PROTAC | PROTAC structure | Cancer | Ref | Target | PROTAC | PROTAC structure | Cancer | Ref |
|---|---|---|---|---|---|---|---|---|---|
FAK (PTK2) | PROTAC-3 |
| TNBC, PC | [256] | p38 | NR-7h |
| BC, CRC, CC | [257] |
FAK (PTK2) | BI-0319 |
| HCC | [246] | Smad3 | PROTAC_Smad3 |
| RCC | [251] |
FAK (PTK2) | BI-3663 |
| HCC | [246] | Src | ND1-YL2 |
| TNBC | [252] |
FAK (PTK2) | FC-11 |
| OC, BC, PC, BL | [247] | Src | 12b |
| BC, NSCLC | [248] |
IGF-1R | 12b |
| BC, NSCLC | [248] | TCF | ARV771 |
| DLBCL | [253] |
p38 | SJFα |
| BC, CC | [249] | TGF-β1 | DT-6 |
| HCC, BC, NSCLC | [254] |
p38 | PROTAC 1 |
| BC, CC | [250] | β-catenin | xStAx-VHLL |
| CRC | [255] |
