Fig. 2
From: Exosomes in the hypoxic TME: from release, uptake and biofunctions to clinical applications
The heterogeneities of exosomes and their biofunction in the hypoxic TME. Different colors for cells represent different kinds and status (such as hypoxia) of cells in tumour microenvironment, indicating tumour heterogeneities. Different colors for exosomes represent heterogeneities in exosomal cargoes and cellular origins. Similar colors between cells and exosomes represent heterogeneities in exosomal origin. Different diameters represent heterogeneities in exosomal size. The outer circle of the picture represents the hallmarks of cancer. Red arrowhead represents that hypoxic tumour-derived exosomes influence corresponding cancer hallmarks and these arrowheads indicate heterogeneities in biofunctions medicated by exosomes. Blue dotted line represents it is too early to draw a conclusion that corresponding hallmarks are affected by hypoxic tumour-derived exosomes [190]