Table 1 Clinical trials about exosome biomarkers
From: Exosomes in the hypoxic TME: from release, uptake and biofunctions to clinical applications
Investigators or contacts | Start time | Tumour | Estimated or actual enrollment | Time perspective | Origin | Potential marker | NCT number |
|---|---|---|---|---|---|---|---|
Yuhui Shen et al. [86] | 2017 | Osteosarcoma | 40 | Prospective | Blood | RNA | NCT03108677 |
Shonit Punwani et al. [87] | 2015 | Prostate Cancer | 130 | Prospective | Blood | HER | NCT02935816 |
Shu Zhang et al. [88] | 2018 | Pancreatic Cancer | 30 | Prospective | Blood | mRNA | NCT03821909 |
Hyun Koo et al. [89] | 2020 | Lung Cancer | 470 | Retrospective | Blood | Protein | NCT04529915 |
Olivier Bouché et al. [90] | 2021 | Colorectal Cancer | 80 | Cross-Sectional | Blood | Macromolecules, integrins, metallo proteases | NCT04394572 |
Lei Li et al. [91] | 2018 | Ovarian Cancer | 160 | Prospective | Blood | miRNA, lncRNA | NCT03738319 |
Alice HERVIEU et al [92]. | 2018 | Sarcoma | 30 | Prospective | Blood | Concentration | NCT03800121 |
Lin Miao et al. [93] | 2017 | Cholangiocarcinoma | 80 | Prospective | Blood | ncRNAs | NCT03102268 |
Henri MONTAUDIE et al. [94] | 2014 | Melanoma | 15 | Prospective | Blood | Concentration, size | NCT02310451 |
Julie ABRAHAM et al. [95] | 2019 | Non-Hodgkin B-cell Lymphomas | 90 | Prospective | Blood | CD20, PDL-1 | NCT03985696 |
Roger Tun et al. [96] | 2014 | Prostate Cancer | 2000 | Prospective | Urine | RNA gene signature | NCT02702856 |
Carl A Olsson et al. [97] | 2020 | Bladder Cancer | 3000 | Prospective | Urine | the expression profiles of the sncRNAs | NCT04155359 |
CHIH-YUAN WANG et al. [98] | 2016 | Thyroid Cancer | 22 | Prospective | Urine | Uncertain | NCT02862470 |
Nicolas MOTTET et al. [99] | 2020 | Clear Cell Renal Cell Carcinoma | 100 | Prospective | Urine | CD9+/CA9+ exosomes, CD9+/VGEFR2+ exosomes, CD9+/CD63+/CD81+/CA9+ exosomes, | NCT04053855 |
Roger Tun et al. [100] | 2016 | Prostate Cancer | 532 | Prospective | Urine | 3-gene expression | NCT03031418 |
Andrew Cowan et al. [101] | 2015 | Oropharyngeal Squamous Cell Carcinoma | 30 | Prospective | Primary cell cultures | Protein Signature | NCT02147418 |