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Fig. 6 | Molecular Cancer

Fig. 6

From: Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC

Fig. 6

CircUSP7 promotes NSCLC progression in a CD8+ T cell-dependent manner and leads to resistance to anti-PD1 therapy. a The relative expression levels of circUSP7 in the serum exosomes from HuNSG mice. b and c The data are expressed as the mean tumour volume (the data are presented as the mean ± SD; n = 6). d The data are expressed as the percent of tumours with inhibited growth (the data are presented as the mean ± SD; n = 6). e Comparison of the OS curves for mice with xenograft NSCLC tumours with high and low circUSP7 expression that were treated with Opdivo. f The expression of circUSP7 in the CD8+ T cells from NSCLC patient tissues (n = 30). g CD8-positive cells in NCI-H460-circUSP7 or NCI-H460-mock cell-derived tissues were analysed by IHC. The data are presented as the mean ± SD; *P < 0.05, **P < 0.01

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