Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC

Table 1 Correlation between circ USP7 and clinical characteristics in 126 NSCLC patients

Variables	CircUSP7 expression level		p value
Variables	Low	High	p value
Age
60<	31	34	0.722
60≥	32	29	0.722
Gender
Male	35	39	0.587
Female	28	24	0.587
Smoking status
Smokers	40	43	0.707
Nonsmokers	23	20	0.707
Histological type
Squamous cell carcinoma	18	21	0.700
Adenocarcinomas	45	42	0.700
Tumor stage
I-II	27	34	0.285
III-IV	36	29	0.285
Tumor size
≤ 3	36	21	0.012
> 3	27	42	0.012
Lymph node metastasis
Yes	20	34	0.019
No	43	29	0.019
Intravascular cancer embolus
Yes	17	29	0.041
No	46	34	0.041
Differentiation
Well and moderate	37	35	0.857
Poor	26	28	0.857

ISSN: 1476-4598