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Fig. 10 | Molecular Cancer

Fig. 10

From: circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis

Fig. 10

Knockdown of circCHST15 inhibits the growth and metastasis of RCC cells in vivo. A-D 786-O cells stably transfected with sh-control or sh-circCHST15 were injected subcutaneously into the left axilla of BALB/c nude mice. Tumor volume and weight were dramatically decreased in circCHST15 knockdown group. E HE staining and IHC analysis of EIF4EBP1, Vimentin, N-cadherin and E-cadherin expression in subcutaneous xenograft tumors. Knockdown of circCHST15 could up-regulate E-cadherin and down-regulate EIF4EBP1, Vimentin and N-cadherin expression. F Bioluminescence of the lung metastatic nodules was detected by an in vivo bioluminescence imaging system. G Representative images of HE staining analysis of the lung metastatic nodules in each group. H lung metastatic nodules were enucleated and measured. The numbers of lung metastatic nodules were significantly decreased in circCHST15 knockdown group. I Schematic diagram shows that circCHST15 promotes RCC cells proliferation and metastasis through miR-125a-5p/EIF4EBP1 axis

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Molecular Cancer

ISSN: 1476-4598