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Fig. 3 | Molecular Cancer

Fig. 3

From: circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis

Fig. 3

Knockdown/overexpression of circCHST15 suppresses/promote RCC cells proliferation, migration and invasion in vitro. A-E 786-O and CAKI-1 cells after transfection of circCHST15-siRNA or siRNA-control. F-J. A498 and HK2 cells after stable transfection of circCHST15 or vector. A, F qRT-PCR analysis of circCHST15 and CHST15 mRNA in RCC cells and HK2 cells. B-C G-H Cell proliferation ability of RCC cells and HK2 cells was evaluated by colony formation assay and CCK8 assay. D, I Cell migration capability of RCC cells and HK2 cells was evaluated by wound healing assays. E-J The influence on cell migration and invasion abilities of RCC cells and HK2 cells was assessed by transwell migration and matrigel invasion assays

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Molecular Cancer

ISSN: 1476-4598