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Fig. 7 | Molecular Cancer

Fig. 7

From: CircDOCK1 promotes the tumorigenesis and cisplatin resistance of osteogenic sarcoma via the miR-339-3p/IGF1R axis

Fig. 7

CircDOCK1 regulates the sensitivity of OS cells to cisplatin. A Relative viability of OS cells after 48 h of treatment with cisplatin at the specified concentrations. B The IC50 of OS cells treated with cisplatin. C The transcript levels of circDOCK1 and IGF1R in the hFOB 1.19, MG63, MG63/DDP, U2OS and U2OS/DDP cell lines (normalized to hFOB 1.19 cells). D Cell growth of MG63 cells and MG63/DDP cells after 48 h of treatment with cisplatin at the specified concentrations. E The IC50 of MG63 cells and MG63/DDP cells treated with cisplatin. F Cell apoptosis of MG63/DDP cells cotransfected with the miR-339-3p inhibitor and circDOCK1 siRNA. G Xenograft tumors from euthanized mice with or without cisplatin treatment. H Volumes of xenograft tumors. I The transcript levels of IGF1R and circDOCK1 in xenograft tumors (normalized to PBS + sh-NC). The data are presented as the mean ± SD of three independent experiments. **P < 0.01, ***P < 0.001

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