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Fig. 7 | Molecular Cancer

Fig. 7

From: Long non-coding RNA NORAD/miR-224-3p/MTDH axis contributes to CDDP resistance of esophageal squamous cell carcinoma by promoting nuclear accumulation of β-catenin

Fig. 7

The NORAD/miR-224-3p/MTDH axis contributes to CDDP resistance of ESCC in vivo. a KYSE30/CDDP-R cell-formed xenograft tumors of sacrificed mice with or without CDDP treatment (3 mg/kg, three times a week) at the end of the experiment and their growth curves. b KYSE30 cell-formed xenograft tumors of sacrificed mice with or without CDDP treatment (3 mg/kg, three times a week) at the end of the experiment and their growth curves. c Representative images of IHC staining of MTDH in xenograft tumors (× 100). Scale bars, 200 μm. d Representative images of nuclear and cytoplasmic expression of MTDH in xenograft tumors, detected by IHC (× 200). Scale bar, 20 μm. e Representative images of CDDP-induced γH2AX and cleaved caspase-3 in KYSE30/CDDP-R cell-formed xenograft tumors, detected by IHC (× 200). Scale bar, 20 μm. f IHC scores of γH2AX and cleaved caspase-3 in KYSE30/CDDP-R cell-formed xenograft tumors. g The summary figure showing the effect of the NORAD/miR-224-3p/MTDH axis in ESCC. Error bars indicate SD. *P < 0.05, **P < 0.01, ***P < 0.001

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