Crosstalk between autophagy and microbiota in cancer progression

Wang, Yu; Du, Jiang; Wu, Xuemei; Abdelrehem, Ahmed; Ren, Yu; Liu, Chao; Zhou, Xuan; Wang, Sinan

doi:10.1186/s12943-021-01461-0

Molecular Cancer

Table 3 Bacteria involved in autophagy-regulated tumors

From: Crosstalk between autophagy and microbiota in cancer progression

Bacteria	Autophagy promotion / inhibition	ATGs	Stage of autophagy	Cancer type	Tumor promotion / suppression	Tumor behavior	Molecular mechanism	Ref.
Helicobacter pylori	Inhibit autophagy	LC3 p62	Autophagy maturation	Gastric cancer	Tumor promotion	Tumorigenesis	H. pylori inhibits autophagy and induces the collection of p62 to promote gastric tumorigenesis.	[110]
	Inhibit autophagy	LC3 p62	Autophagy maturation	Gastric cancer	Tumor promotion	Migration and invasion	CagA promotes miR-543 overexpression which can suppress autophagy, leading to tumor cell migration and invasion.	[121]
	Promote autophagy	LC3 Beclin-1	Autophagy nucleation and maturation,	Colon cancer	Tumor promotion	Proliferation and invasion	CagA-positive H. pylori decreases miR-125b-5p level and induce autophagy for promotes the proliferation and invasion of colon cancer.	[124]
Fusobacterium nucleatum	Promote autophagy	ULK1 ATG7	Autophagy initiation and maturation	Colorectal cancer	Tumor promotion	Chemoresistance	F. nucleatum medicates CRC chemoresistance via deletion of miR18a*/4802 targeting ULK1/ATG7.	[36]
	Promote autophagy	ATG7 LC3	Autophagy maturation	Esophageal squamous cell carcinoma	Tumor promotion	Chemoresistance	F. nucleatum induces ESCS chemoresistance by modulating the endogenous LC3 and ATG7 expression, as well as autophagosomes formation.	[115]
	Promote autophagy	LC3 Beclin1	Autophagy nucleation and maturation,	Colorectal cancer	Tumor promotion	Metastasis	F. nucleatum promotes CRC metastasis by activating autophagy signaling via CARD3.	[130]
Porphyromonas gingivalis	Promote autophagy	LC3	Autophagy maturation	Oral cancer	Tumor suppression	Proliferation	P. gingivalis infection promotes autophagy and controls cell proliferation and G1 arrest in host oral cancer cells.	[35]
Salmonella typhimurium	Promote autophagy	ATG-5 Beclin1	Autophagy maturation	Liver cancer Gastric cancer	Tumor suppression	Proliferation	Inhibiting autophagy enhances the cancer-cell killing ability of S. typhimurium.	[134]
Campylobacter jejuni	Inhibit autophagy	ATG-5 ATG-12	Autophagy maturation	Prostate cancer	Tumor suppression	Radioresistance	C. jejuni suppresses autophagy via CDT and then enhances PC cells radiosensitivity.	[135]

LC3 light chain 3, CagA cytotoxin-associated gene A, ULK1 unc-51-like kinase 1, ATG7 autophagy-related gene 7, CARD3 caspase activation and recruitment domain 3, CDT cytolethal distending toxin

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