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Table 4 Autophagy related drugs and associated clinical trials

From: Crosstalk between autophagy and microbiota in cancer progression

Drugs

Cancer type

Clinical trial / Animal experiment

Phase

Ref. / Trial ID

Chloroquine

Small cell lung cancer

Clinical trial

Phase I

NCT00969306

 

Small cell lung cancer

Clinical trial

Phase I

NCT01575782

 

Breast cancer

Clinical trial

Phase II

NCT02333890

Hydroxychloroquine

Estrogen receptor-positive breast cancer

Clinical trial

Phase Ib/II

NCT02414776

 

Prostate carcinoma

Clinical trial

Phase I

NCT02421575

 

Solid tumors

Clinical trial

Phase I

NCT03015324

 

Melanoma

Clinical trial

Phase I

NCT00962845

 

Hepatocellular carcinoma

Clinical trial

Phase I/II

NCT02013778

 

B-CLL

Clinical trial

Phase II

NCT00771056

 

Renal cancer

Clinical trial

Phase Ib

NCT01144169

Sorafenib

Hepatocellular carcinoma

Clinical trial

Phase Ib/II

NCT03211416

Lys05

Melanoma, colon cancer

Animal experiment

/

[136]

DQ661

Melanoma, pancreatic cancer, colorectal cancer

Animal experiment

/

[137, 138]

SAR405, SB02024

Melanoma, colorectal cancer

Animal experiment

/

[139]

Mefloquine

Pancreatic ductal adenocarcinoma

Animal experiment

/

[140]

Spautin-1

Prostate cancer

Animal experiment

/

[141]

 

Melanoma

Animal experiment

/

[142]

Rapamycin

Bladder cancer

Clinical trial

Phase II

NCT04375813

 

Advanced cancers

Clinical trial

Phase Ib

NCT00707135

 

HNSCC

Animal experiment

/

[143]

 

Lung squamous cell carcinoma

Animal experiment

/

[144]

Temsirolimus

Prostate cancer

Clinical trial

Phase II

NCT00919035

 

Advanced cancers

Clinical trial

Phase I/II

NCT00877773

 

HNSCC

Clinical trial

Phase II

NCT01172769

 

Advanced bladder cancer

Clinical trial

Phase II

NCT01827943

 

Cervical cancer

Clinical trial

Phase II

NCT01026792

 

Metastatic neuroendocrine carcinoma

Clinical trial

Phase II

NCT00093782

 

Liver cancer

Clinical trial

Phase II

NCT01079767

 

Endometrial carcinoma

Clinical trial

Phase IIa

NCT02093598

  1. HNSCC head and neck squamous cell carcinoma, Trial ID registered number at Clinical Trials.gov