Fig. 1

Identification of regulators involved in antitumor immune response by integrative analyses of immune-oncology screening data. A Schematic illustration of the process of pooled CRISPR/Cas9 knockout screens using tumor/immune co-culture systems. This screening approach was adopted by most of the included experiments. B Distribution of screens across different cancer types. C Common sensitizer genes (left) and resistor genes (right) identified by different screens. The top 10 genes were labeled in each plot. D Association between the functional status of sensitizers/resistors and the abundance of immune/cytolytic activity/MHC scores. Statistical significance of associations was determined using regression analysis, adjusting for cancer type. Comparison between sensitizers and resistors was conducted using Fisher’s exact tests. E Intersections of the resultant genes from three different filtering approaches. The results of sensitizers (left) and resistors (right) were displayed separately