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Fig. 2 | Molecular Cancer

Fig. 2

From: Integrative analysis of CRISPR screening data uncovers new opportunities for optimizing cancer immunotherapy

Fig. 2

The overall characterization of sensitizer and resistor genes. A Similarity matrix representing the Gene Ontology (GO)-based functional similarity (FS) scores between each pair of sensitizers/resistors. B GO functional annotation of sensitizer genes (upper) and resistor genes (lower) based on the occurrence frequency. Only the top five terms were presented. C Distribution of the inactivation event numbers of sensitizers (left) and resistors (right) across different TCGA cancer types. D Heatmap showing the inactivation events of subtype-specific sensitizer/resistor genes across six immune subtypes. Subtype-specific genes were determined using logistic regression. Only statistically significant genes were presented. E Functional annotation of subtype-specific sensitizer/resistor genes using information from ImmPort (immport.org). F Distribution of the inactivation event numbers of sensitizers (upper) and resistors (lower) across different immune subtypes

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