Skip to main content
Fig. 4 | Molecular Cancer

Fig. 4

From: CRISPR screens uncover protective effect of PSTK as a regulator of chemotherapy-induced ferroptosis in hepatocellular carcinoma

Fig. 4

PSTK knockout increases the sensitivity of HCC to therapeutic agents in spheroid cultures and in vivo. A-B Longitudinal changes in the volume of spheroids prepared from PSTK-KO and control cells under the indicated treatments over a 21-day period (n=6). Right: the final spheroids in the indicated groups. Scale bar: 500 μm. C Changes in tumor volumes over time for mice implanted with PSTK-KO Hep3B cells and control cells and treated with Abemacicilb or vehicle. D Measures of tumor volume and tumor weight values in mice bearing PSTK-KO Hep3B tumor xenografts following treatment with Abemaciclib or vehicle control. E-F Longitudinal changes in tumor volume and final tumor weight values for xenograft-bearing mice treated with Sorafenib. G-H Longitudinal changes in tumor volume and final tumor weight values in xenograft-bearing mice treated with Erastin. *p<0.05; **p<0.01; ***p<0.001; Student’s t-test

Back to article page

Molecular Cancer

ISSN: 1476-4598