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Fig. 4 | Molecular Cancer

Fig. 4

From: CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer

Fig. 4

circIL4R facilitates the proliferation, migration and invasion of CRC cells in vitro. a and b qRT-PCR validation of circIL4R and IL4R mRNA expression in HCT116 and LoVo cells transfected with siRNAs and overexpression plasmids, respectively. c and d The viability curves of CRC cells with knockdown or overexpression of circIL4R were detected by the CCK-8 assay at the indicated time points. e and f A colony formation assay was conducted to determine the proliferation of CRC cells stably transfected with sh-Ctrl, sh- circIL4R, vector or circIL4R. g and h An EdU assay was performed to assess the proliferation ability of CRC cells transfected with the indicated siRNAs or plasmids. i to l Representative images and quantification of Transwell and wound healing assays of CRC cells transfected with the indicated siRNAs or plasmids. The data are presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Cancer

ISSN: 1476-4598