Fig. 2
From: circCDYL2 promotes trastuzumab resistance via sustaining HER2 downstream signaling in breast cancer
circCDYL2 promotes drug resistant to trastuzumab in the PDX model. A The establishment of xenograft model derived from trastuzumab-resistant patient tissues. B Tumor derived from trastuzumab-resistant patient was measured in Balb/c nude mice. C, D Tumor volume (C) and tumor weight (D) was measured after tumor excision. E IHC staining of Ki-67, P-ERK, ERK, P-AKT and AKT and ISH detection of circCDYL2 in xenograft tumors. Scale bar, 50 μm. n = 5 animals per group