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Fig. 7 | Molecular Cancer

Fig. 7

From: circCDYL2 promotes trastuzumab resistance via sustaining HER2 downstream signaling in breast cancer

Fig. 7

circCDYL2 promotes trastuzumab resistant of BC cells. A Representative images of tumors, which were formed by empty vector- or circCDYL2-transduced P-SK-BR-3 (upper) and negative control- or circCDYL2-knockdown SK-BR3-R (lower) cell lines, treated with either FAK inhibitor or GRB7 inhibitor combined with or without trastuzumab. B The volume of indicated tumors was measured on the indicated days. C The weight of indicated tumors were measured after tumor excision. D IHC staining of Ki-67, GRB7, FAK, P-ERK, ERK, P-AKT and AKT and ISH detection of circCDYL2 in the indicated tumors. Scale bar, 50 μm. n = 5 animals per group

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