Table 2 Univariate and multivariate analyses of clinical parameters on clinical outcomes

Progression-free survival

Sex (Female/male)

1.124

0.727-1.737

0.599

Age (≥65/<65)

0.990

0.312-3.140

0.986

Smoking (yes/no)

0.825

0.412-1.651

0.587

ECOG PS (1/0)

1.296

0.716-2.348

0.392

Stage (IV/III)

1.577

0.943-2.636

0.082

1.415

0.797-2.511

0.236

PD-L1 expression (<1/>1)

1.570

1.011-2.439

0.045

1.604

1.033-2.493

0.035

Number of metastases (>3/<3)

1.580

1.0168-2.458

0.042

1.204

0.596-1.759

0.933

Liver metastasis (yes/no)

1.545

0.769-3.107

0.222

Brain metastasis (yes/no)

0.772

0.107-5.577

0.798

Sum of diameters (<median/>median)

0.941

0.609-1.453

0.784

Tissue TMB at baseline (<75%/>75%)

1.483

0.982-2.255

0.064

1.574

0.993-2.470

0.084

Blood TMB at baseline (<75%/>75%)

1.186

0.781-1.820

0.421

On-treatment blood TMB (<75%/>75%)

0.190

0.105-0.342

<0.001

0.189

0.101-0.358

<0.001

Overall survival

Sex (Female/male)

1.254

0.301-5.223

0.755

Age (≥65/<65)

1.489

0.812-2.729

0.198

Smoking (yes/no)

0.777

0.277-2.180

0.632

ECOG PS (1/0)

1.184

0.525-2.670

0.683

Stage (IV/III)

1.106

0.564-2.169

0.770

PD-L1 expression (<1/>1)

1.893

1.010-3.547

0.046

2.175

1.154-4.101

0.016

Number of metastases (<3/>3)

0.525

0.286-0.962

0.037

0.665

0.355-1.245

0.202

Liver metastasis (yes/no)

1.590

0.664-3.806

0.298

Brain metastasis (yes/no)

1.528

0.209-11.156

0.676

Sum of diameters (<median/>median)

1.039

0.566-1.907

0.901

Tissue TMB at baseline (<75%/>75%)

1.272

0.681-2.376

0.451

Blood TMB at baseline (<75%/>75%)

0.829

0.447-1.537

0.551

On-treatment blood TMB (<75%/>75%)

0.144

0.074-0.281

<0.001

0.152

0.075-0.308

<0.001