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Fig. 2 | Molecular Cancer

Fig. 2

From: CircRTN4 promotes pancreatic cancer progression through a novel CircRNA-miRNA-lncRNA pathway and stabilizing epithelial-mesenchymal transition protein

Fig. 2

circRTN4 promotes PDAC cell growth, migration, and invasion. A CircRTN4 knockdown inhibited PDAC cell growth. B CircRTN4 knockdown inhibited PDAC clonogenic ability. C Cell cycle was arrested at G0-G1 phase after circRTN4 knockdown in PANC-1 cells. D CircRTN4 knockdown resulted in the increase in Annexin V staining (red) in PDAC cells. Nuclei were stained by DAPI (blue). E Apoptosis markers PARP was cleaved, and Bcl-2 was reduced after circRTN4 knockdown in PANC-1 cells. F, G CircRTN4 knockdown inhibited (F) cell migration and (G) cell invasion in PDAC cells. Cells in invasion assay were stained by crystal violet. Data represent mean ± SD from at least three independent experiments (*p < 0.05; **p < 0.01; ***p < 0.001)

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Molecular Cancer

ISSN: 1476-4598