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Fig. 1 | Molecular Cancer

Fig. 1

From: A liquid biopsy signature predicts treatment response to fluoropyrimidine plus platinum therapy in patients with metastatic or unresectable gastric cancer: implications for precision oncology

Fig. 1

A 9-miRNA panel discovered using small RNA sequencing data identifies patients responsive to systemic chemotherapy. A A volcano plot illustrates 9 miRNAs discovered from several bioinformatic approaches in sera from 12 patients with mGC. Among 21 miRNA candidates that were differentially expressed in responders and non-responders, logistic regression and average expression analyses reduced them to a 9-miRNA panel. B A volcano plot depicts differential expression of all 9 miRNAs after average expression analysis; 5 candidates were upregulated (red) and 4 were downregulated (blue) in responders vs, non-responders. C A principal component analysis shows separate clusters for responder and non-responder groups. D A heatmap illustrates clustering of miRNA expression based on response to systemic chemotherapy and estimated probability of chemo-responsiveness from the logistic regression analysis. E A waterfall plot demonstrates the ability of the 9-miRNA panel to discriminate responders from non-responders

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