Table 1 The synergy between targeting metabolism and existing anti-cancer therapies
From: Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy
Existing Anti-cancer Therapies | Metabolic Manipulation | Purpose Of Manipulation | Synergistic Mechanism | Reference |
|---|---|---|---|---|
Adoptive transfer protocols of autologous T cells | Glucose analog 2-DG | Inhibiting glycolysis | Generation of T cells with memory phenotype | Sukumar et al .[129] |
Oncolytic viruses | Engineering oncolytic viruses to express leptin | Increasing FAO and OXPHOS and promoting mitochondrial biogenesis | Differentiation of T cells into memory-like phenotype | Rivadeneira et al .[130] |
Immune checkpoint blockade | Mitochondrial activators | Activating FAO and OXPHOS and promoting mitochondrial expansion | Enhanced activation and proliferation of CTLs | Chamoto et al .[131] |