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Fig. 6 | Molecular Cancer

Fig. 6

From: Circulating extracellular vesicles expressing PD1 and PD-L1 predict response and mediate resistance to checkpoint inhibitors immunotherapy in metastatic melanoma

Fig. 6

PD-L1+ EVs and PD1+ EVs from melanoma and T cells of responders and non-responders enrolled in the validation cohort. A Scatter plots with median of the percentage of PD-L1+ EVs from melanoma and PD1+ EVs from CD8 T cells isolated from responders (9) and non-responders (13) enrolled in the validation independent cohort (Mann Whitney t test **p < 0.05, *** p < 0.001). B Kaplan–Meier survival curve analysis according to PD-L1+ EVs quartiles, with PD-L1+ EVs from melanoma as respect to PFS, and according to PD1+ EVs quartiles, with PD1+ EVs from T cells as respect to PFS. C Univariable Cox-hazard regression analysis (PFS)

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Molecular Cancer

ISSN: 1476-4598