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Fig. 2 | Molecular Cancer

Fig. 2

From: Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy

Fig. 2

The immunological synapse between tumor-derived exosomes and NK cells. Tumor cells release a large amount of immunoinhibitory exosomes into tumor microenvironment and circulation which can interact with NK cells and deliver their suppressive content into these cells. A plethora of biomolecules, including MICA/B, ULBPs, PD-L1, Fas-L, TGF-b, and B7-3 presents on exosomes that can be engaged with their cognate receptors on NK cells and induce downstream signaling, inhibiting their anti-tumor activity

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Molecular Cancer

ISSN: 1476-4598