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Fig. 1 | Molecular Cancer

Fig. 1

From: circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-β/Smad signaling

Fig. 1

Identification analysis of a novel circular RNA generated from the PTEN gene. A. The expression profiles of circRNAs derived from the PTEN gene in the normal human colonic epithelial cell line NCM460 and colon cancer cell lines. B. qRT-PCR assay showing the relative levels of circPTEN1 and circPTEN2 (normalized to β-actin) in the peritumor and tumor tissues of colon cancer (n = 150). ****, P < 0.0001. ns: no statistically significance. C. circPTEN1 expression was significantly lower in tumor tissues than in peritumor tissues in 80% of colon cancer patients. D. Fluorescence in situ hybridization assay was conducted to determine the expression of circPTEN1 in the peritumor and tumor tissues of colon cancer. N: peritumor tissue, T: tumor tissue. The scale bars represent 200 μm. E. Kaplan-Meier analysis of correlations between circPTEN1 expression levels and OS (overall survival) of 150 colon cancer patients

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