A signature of saliva-derived exosomal small RNAs as predicting biomarker for esophageal carcinoma: a multicenter prospective study

Table 2 Performance of sesncRNAs test to differentiate ESCC patients from healthy subjects in CHSUMC and ATH cohorts

Variables	Cohorts	Cancer	Test Positive (n)	Test Negative (n)	Total (n)	Sensitivity	Specificity	PPV	NPV
tRNA-GlyGCC-5	CHSUMC	Absent	10	110	120	79.00%	91.67%	94.05%	72.37%
		Present	158	42	200
		Total	168	152	320
sRESE	CHSUMC	Absent	14	106	120	77.00%	88.33%	91.67%	69.73%
		Present	154	46	200
		Total	168	152	320
Bi-sesncRNA signature	CHSUMC	Absent	7	113	120	90.50%	94.20%	96.28%	85.61%
		Present	181	19	200
		Total	188	132	320
	ATH	Absent	9	51	60	87.14%	85.00%	93.13%	75.00%
		Present	122	18	140
		Total	131	68	200

PPV positive predictive value, NPV negative predictive value
The cutoff value calculated in CHSUMC cohort was applied in the ATH cohort
Test Positive in this analysis is based on a sesncRNA level or RSD higher than cutoff value; the remaining individuals were classified as Test Negative

ISSN: 1476-4598