Table 4 Univariate and multivariate Cox proportional hazards analyses of survival in ESCC patients of CHSUMC cohort
Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Age (years) | ||||
  > 60 vs. ≤60 | 1.258 (0.817 to 1.936) | 0.297 | 0.938 (0.596 to 1.475) | 0.782 |
Gender | ||||
 Male vs. Female | 0.792 (0.502 to 1.249) | 0.315 | 0.656 (0.399 to 1.078) | 0.096 |
Histological differentiation | ||||
 Poor vs. Well/Moderate | 1.708 (1.247 to 2.339) | 0.001 | 1.473 (1.039 to 2.088) | 0.030 |
Largest tumor dimension (cm) | ||||
  ≥ 5 vs. < 5 | 1.748 (1.120 to 2.728) | 0.014 | 1.520 (0.955 to 2.421) | 0.078 |
TNM Stage | ||||
 III vs. I/II | 2.709 (1.645 to 4.463) | < 0.001 | 1.688 (0.985 to 2.894) | 0.057 |
Bi-sesncRNA signature | 2.062 (1.678 to 2.535) | < 0.001 | 1.983 (1.550 to 2.535) | < 0.001 |