Classification | Cancer Type | M6A Related Enzymes | Biological Behavior Changes | Related Enzymes | Official Full Name of the Enzymes | References |
---|---|---|---|---|---|---|
Glucose metabolism | Cervical cancer | METTL3; YTHDF1 | Promote Warburg effect and glycolysis | HK2 | Hexokinase 2 | [122] |
Gastric cancer | WTAP | Promote the proliferation and glycolysis of tumor cells | HK2 | Hexokinase 2 | [123] | |
Colorectal cancer | METTL3; IGF2BP2; IGF2BP3 | Activate glycolysis pathways | HK2; SLC2A1 | Hexokinase 2; Solute carrier family 2 member 1 | [124] | |
Gastric cancer | KIAA1429 | Promote aerobic glycolysis to promote tumor progression | GLUT1 | Glucose transporter 1 | [126] | |
Pancreatic ductal adenocarcinoma | YTHDC1 | Attenuation Warburg effect to inhibit tumor progression | SLC2A1; HK1 | Solute carrier family 2 member 1; Hexokinase 1 | [127] | |
Bladder cancer | ALKHB5 | Regulate glycolysis pathways and glucose absorption, lactate and ATP production | CK2α | Casein Kinase 2α | [128] | |
Hepatocellular carcinoma | FTO | Accumulate glycolysis into anabolic pathways | PKM2 | Pyruvate Kinase M2 | [129] | |
Colorectal cancer | IGF2BP2 | Promote glycolysis | c-MYC | MYC proto-oncogene | [131] | |
Lung adenocarcinoma | FTO; YTHDF1 | Promote tumor glycolysis and tumorigenesis | c-MYC | MYC proto-oncogene | [132] | |
GBM | FTO | Promote aerobic glycolysis and promote chemoresistance | PDK1 | Pyruvate dehydrogenase kinase 1 | [133] | |
Cervical cancer and Liver cancer | YTHDF1; IGF2BP3 | Promote glycolysis and ATP generation | PDK4 | Pyruvate dehydrogenase kinase 4 | [134] | |
Breast cancer | WTAP | Promote glycolysis and promote tumor progression | ENO1 | Enolase 1 | [135] | |
Renal cell carcinoma | METTL14 | Promote tumor cell distal lung metastasis | BPTF | Bromodomain PHD finger transcription factor | [136] | |
Fatty acid metabolism | Hepatocellular carcinoma | FTO; YTHDF2 | Influence the content of adipogenic enzymes and intracellular lipids | FASN | Fatty acid synthase | [141] |
Esophageal cancer | HNRNPA2B1 | Promote cellular lipid accumulation to promote tumor progression | ACLY; ACC1 | ATP citrate lyase; Acetyl-CoA carboxylase | [143] | |
Amino acid metabolism | Renal clear cell carcinoma | FTO | Synthetic death with VHL and activate VEGF and PDGF | SLC1A5 | Solute carrier family 1 member 5 | [146] |
Colorectal cancer | IGF2BP1 | Promote the tumorigenesis | MYC | MYC proto-oncogene | [147] | |
Mitochondrial metabolism | Renal clear cell carcinoma | METTL3 | Regulate one carbon metabolism and aerobic glycolysis of tumor cells | MTHFD2; HIF-2α | Methylenetetrahydrofolate dehydrogenase 2; Hypoxia inducible factor-2α | [151] |
Renal clear cell carcinoma | FTO | Regulate mitochondrial activity and promote oxidative stress and ROS production | PGC-1α | PPARG coactivator 1α | [153] | |
Breast cancer | METTL3 | Inhibit apoptosis of mitochondrial, attenuate resistance to tamoxifen | AK4 | Adenylate kinase 4 | [154] |