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Table 2 The relationship between m6A enzymes and cancer metabolism

From: The role of m6A RNA methylation in cancer metabolism

Classification

Cancer Type

M6A Related Enzymes

Biological Behavior Changes

Related Enzymes

Official Full Name of the Enzymes

References

Glucose metabolism

Cervical cancer

METTL3; YTHDF1

Promote Warburg effect and glycolysis

HK2

Hexokinase 2

[122]

Gastric cancer

WTAP

Promote the proliferation and glycolysis of tumor cells

HK2

Hexokinase 2

[123]

Colorectal cancer

METTL3; IGF2BP2; IGF2BP3

Activate glycolysis pathways

HK2; SLC2A1

Hexokinase 2; Solute carrier family 2 member 1

[124]

Gastric cancer

KIAA1429

Promote aerobic glycolysis to promote tumor progression

GLUT1

Glucose transporter 1

[126]

Pancreatic ductal adenocarcinoma

YTHDC1

Attenuation Warburg effect to inhibit tumor progression

SLC2A1; HK1

Solute carrier family 2 member 1; Hexokinase 1

[127]

Bladder cancer

ALKHB5

Regulate glycolysis pathways and glucose absorption, lactate and ATP production

CK2α

Casein Kinase 2α

[128]

Hepatocellular carcinoma

FTO

Accumulate glycolysis into anabolic pathways

PKM2

Pyruvate Kinase M2

[129]

Colorectal cancer

IGF2BP2

Promote glycolysis

c-MYC

MYC proto-oncogene

[131]

Lung adenocarcinoma

FTO; YTHDF1

Promote tumor glycolysis and tumorigenesis

c-MYC

MYC proto-oncogene

[132]

GBM

FTO

Promote aerobic glycolysis and promote chemoresistance

PDK1

Pyruvate dehydrogenase kinase 1

[133]

Cervical cancer and Liver cancer

YTHDF1; IGF2BP3

Promote glycolysis and ATP generation

PDK4

Pyruvate dehydrogenase kinase 4

[134]

Breast cancer

WTAP

Promote glycolysis and promote tumor progression

ENO1

Enolase 1

[135]

Renal cell carcinoma

METTL14

Promote tumor cell distal lung metastasis

BPTF

Bromodomain PHD finger transcription factor

[136]

Fatty acid metabolism

Hepatocellular carcinoma

FTO; YTHDF2

Influence the content of adipogenic enzymes and intracellular lipids

FASN

Fatty acid synthase

[141]

Esophageal cancer

HNRNPA2B1

Promote cellular lipid accumulation to promote tumor progression

ACLY; ACC1

ATP citrate lyase; Acetyl-CoA carboxylase

[143]

Amino acid metabolism

Renal clear cell carcinoma

FTO

Synthetic death with VHL and activate VEGF and PDGF

SLC1A5

Solute carrier family 1 member 5

[146]

Colorectal cancer

IGF2BP1

Promote the tumorigenesis

MYC

MYC proto-oncogene

[147]

Mitochondrial metabolism

Renal clear cell carcinoma

METTL3

Regulate one carbon metabolism and aerobic glycolysis of tumor cells

MTHFD2; HIF-2α

Methylenetetrahydrofolate dehydrogenase 2; Hypoxia inducible factor-2α

[151]

Renal clear cell carcinoma

FTO

Regulate mitochondrial activity and promote oxidative stress and ROS production

PGC-1α

PPARG coactivator 1α

[153]

Breast cancer

METTL3

Inhibit apoptosis of mitochondrial, attenuate resistance to tamoxifen

AK4

Adenylate kinase 4

[154]