Fig. 3

circCAMSAP1 promotes proliferation and metastasis of NPC cells in vivo. A Representative images of nude mice lung tissues after tail vein injection of NPC cells. Mice were injected with NPC cells after overexpression or knockdown of circCAMSAP1 (Left). The number of nodules on the surface of lung tissues were counted and analyzed (Right). n = 5; ***, p < 0.001; ****, p < 0.0001. B Representative images of hematoxylin and eosin-stained metastatic lung nodules after overexpression or knockdown of circCAMSAP1. × 40, scale bar = 200 μm; × 100, scale bar = 100 μm; × 200, scale bar = 50 μm. C Growth curve of subcutaneous tumor volume in nude mice. Nude mice were injected with NPC cells subcutaneously in the armpit after overexpression or knockdown of circCAMSAP1. n = 5; *, p < 0.05; **, p < 0.01. D-F Image of subcutaneous tumor tissues in nude mice (D), tumor volume (E) and tumor weights (F) show that circCAMSAP1 promoted CNE2 xenograft growth 27 days after subcutaneous injection. n = 5; *, p < 0.05; **, p < 0.01; ***, p < 0.001