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Fig. 8 | Molecular Cancer

Fig. 8

From: Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop

Fig. 8

Schematic illustration of circCAMSAP1 promoting proliferation and metastasis of NPC through a positive SERPINH1/c-Myc feedback. circCAMSAP1 stabilizes SERPINH1 expression by binding to the SERPINH1 3’UTR. The binding of SERPINH1 to c-Myc inhibits the ubiquitination and degradation of c-Myc, leading to CAMSAP1 pre-mRNA transcription and back-splicing under the action of SRSF10, forming a positive feedback on circCAMSAP1 production, resulting in proliferation, migration, and invasion of NPC

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Molecular Cancer

ISSN: 1476-4598