Fig. 3From: Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancerMET therapeutic strategies in the inhibition of cancer survival. Aberrant HGF stimulation of MET in human cancer through paracrine signaling activates the receptor. MET activation results in the recruitment and activation of downstream adaptor proteins and kinase targets resulting in a multitude of effects such as increased cell proliferation, cell cycle progression, scattering, motility, survival, extracellular matrix remodeling, and changes in metabolism. Therapeutic intervention strategies to block and inhibit MET receptor oncogenic signaling cascade include blocking ligand-receptor interaction, preventing receptor dimerization, blocking MET kinase intrinsic activity, and inhibiting specific downstream signal transducersBack to article page