Table 1 Clinical characteristics of patients and healthy participants in the tissue validation, and retrospective and prospective serum cohorts
| Â | Tissue Cohort | Serum Cohorts (Retrospective) | Serum Cohorts (Prospective) | ||||
|---|---|---|---|---|---|---|---|
Validation Cohort (n = 64) | Prioritization Cohort (n = 100) | Training Cohort (n = 408) | Validation Cohort 1 (n = 126) | Validation Cohort 2 (n = 165) | Training Cohort (n = 185) | Validation Cohort (n = 188) | |
ESCC | 32 (50) | 50 (50) | 280 (68.6) | 106 (84.1) | 123 (74.5) | 89 (48.1) | 89 (47.3) |
Sex | |||||||
 Men | 26 (81.2) | 29 (58) | 188 (67.1) | 66 (62.3) | 93 (75.6) | 79 (88.8) | 78 (87.6) |
 Women | 6 (18.8) | 21 (42) | 92 (32.9) | 40 (37.7) | 30 (24.4) | 10 (11.2) | 11 (12.4) |
Age, median (range), y | 60 (54–77) | 55 (35–70) | 59 (28–87) | 56 (30–76) | 65 (44–84) | 62 (55–67) | 62 (55–67) |
Cancer stage | |||||||
 I | 6 (18.8) | 21 (42) | 8 (2.8) | 43 (40.6) | 22 (17.9) | 12 (13.5) | 13 (14.6) |
 II | 10 (31.2) | 11 (22) | 61 (21.8) | 23 (21.7) | 30 (24.4) | 19 (21.3) | 20 (22.5) |
 III | 16 (50) | 18 (36) | 180 (64.3) | 40 (37.7) | 61 (49.6) | 25 (28.1) | 26 (29.2) |
 IV |  |  | 21 (7.5) |  | 10 (8.1) | 31 (34.8) | 30 (33.7) |
 Unstaged |  |  | 10 (3.6) |  |  | 2 (2.3) |  |
Differentiation | |||||||
 Well (W) |  |  |  |  |  | 8 (9.0) | 11 (12.4) |
 Moderate (M) |  |  |  |  |  | 23 (25.8) | 27 (30.3) |
 P (Poor) |  |  |  |  |  | 16 (18.0) | 16 (18.0) |
 Unknown |  |  |  |  |  | 42 (47.2) | 35 (39.3) |
Location | |||||||
 Lower (L) |  |  |  |  |  | 38 (42.7) | 32 (35.9) |
 Middle (M) |  |  |  |  |  | 14 (15.7) | 16 (18.0) |
 Upper (U) |  |  |  |  |  | 14 (15.7) | 11 (12.4) |
 Unknown |  |  |  |  |  | 23 (25.9) | 30 (33.7) |
Race | |||||||
 Asian | 32 (100) | 50 (100) |  | 106 (100) | 123 (100) | 89 (100) | 89 (100) |
 Black |  |  | 180 (64.3) |  |  |  |  |
 Mixed-race |  |  | 100 (35.7) |  |  |  |  |
Healthy participants | 32 (50) | 50 (50) | 128 (31.4) | 20 (15.9) | 42 (25.5) | 96 (51.9) | 99 (52.7) |
Sex | |||||||
 Men |  | 31 (62) | 88 (68.8) | 11 (55) | 23 (54.8) | 63 (65.6) | 65 (65.7) |
 Women |  | 19 (38) | 40 (31.2) | 9 (45) | 19 (45.2) | 33 (34.4) | 34 (34.3) |
Age, median (range), y |  | 54 (33–66) | 55 (30–76) | 53 (35–64) | 37 (26–56) | 57 (50–65) | 57 (48–64) |
Race | |||||||
 Asian | 32 (100) | 50 (100) |  | 20 (100) | 42 (100) | 96 (100) | 99 (100) |
 Black |  |  | 81 (63.3) |  |  |  |  |
 Mixed-race |  |  | 47 (36.7) |  |  |  |  |