Fig. 3
From: Insights into N6-methyladenosine and programmed cell death in cancer
M6A and programmed cell death in non-cancer diseases. Enhanced m6A promotes apoptosis to inhibit the development of AKI and ischemic heart diseases. The latter can be aggravated by inhibition of TFEB-mediated autophagy, and TFEB can regulate METTL3 and ALKBH5 expression. M6A regulators suppress the progression of obesity and oligospermatisms via autophagy. M6A regulates PTEN/PI3K/AKT/GSK3βto inhibit pyroptosis, thus fighting against I/R injury. METTL3 upregulation modulates the development of DR and AS/ACS through pyroptosis