Insights into N6-methyladenosine and programmed cell death in cancer

Liu, Li; Li, Hui; Hu, Dingyu; Wang, Yanyan; Shao, Wenjun; Zhong, Jing; Yang, Shudong; Liu, Jing; Zhang, Ji

doi:10.1186/s12943-022-01508-w

Molecular Cancer

Table 1 The clinical application of m6A and PCD

From: Insights into N6-methyladenosine and programmed cell death in cancer

M6A associated molecules	Types of programmed cell death pathways	Molecular mechanisms	The corresponding cancers	Clinical application	Ref.
FTO	Apoptosis	Increased MZF1 expression	LUSC	Prognosis and therapy	[123]
METTL3 and IGFBP2	Apoptosis	Promoted the stability of SEC62 mRNA	Gastric cancer	Prevention and management	[124]
METTL3 and YTHDF2	Apoptosis	Mediated LHPP and NKX3–1 mRNA	Prostate cancer	Diagnosis and therapy	[125]
HNRNPC	Apoptosis	Downregulated miR-21 and AKT phosphorylation	Ovarian cancer	Prognosis	[126]
METTL3	Autophagy	Stimulated autophagy of ARHGAP5-AS1 or destabilizing ARHGAP5	Gastric cancer	Anti- chemoresistance and prognosis	[127]
METTL3	Apoptosis	Impinged on critical cellular processes	Cervical cancer	Radio/ chemo-resistance	[128, 129]
METTL14	Apoptosis	Targeted CXCR4 and CYP1B1	Breast cancer	Diagnosis, therapy and prognosis	[94]
WTAP	Apoptosis	Affected PI3K/AKT signaling	AML	Prognosis	[130]
WTAP	Apoptosis	Regulated DUSP6	NKTCL	Drug resistance	[131]
YTHDF2	Apoptosis	Reduced the half-life of Tnfrsf2	AML	Therapy	[132]
ALKBH5	Apoptosis	Reduced m6A-methylated pre-miR-181b-1 and YAP	Osteosarcoma	Therapy	[133]
ALKBH5 And YTHDF2	Apoptosis		Pancreatic cancer	Diagnosis and therapy	[134]
FTO	Autophagy	Augmented m6A demethylation of ATG5 and ATG7	Ovarian cancer	Diagnosis and therapy	[135]
FTO	Apoptosis	Caused inhibition of MYC/CEBPA signaling	Glioma	Anti-cancer activity	[136]
FTO	Apoptosis	Reduced hypomethylation and Bcl-2 transcripts	AML	Drug resistance	[137]
M6A	Apoptosis	Regulated the Daple/β-catenin/ABCC9 signaling pathway	NPC	Drug resistance	[138]
RBM15	Apoptosis	Upregulated TMBIM6 m6A modification	LSCC	Therapy and Prognosis	[139]
FTO	Autophagy	Reduced m6A methylation of the critical protumorigenic melanoma cell-intrinsic genes containing PD-1(PDCD-1), CXCR4 and SOX10 and maintaining their mRNA stability	Melanoma	Immune therapy resistance	[103]
M6A writers	Apoptosis	Correlated with drugs which targeted oncogenic related pathways, such as MAPK, EGFR, and mTOR signaling pathways	Colorectal cancer	Immune therapy resistance	[140]

LUSC lung squamous cell carcinoma, NKTCL Natural killer/T-cell lymphoma, DUSP6 dual-specificity phosphatases 6, YAP Yes-associated protein 1

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ISSN: 1476-4598

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