Fig. 2
From: CircPVT1: a pivotal circular node intersecting Long Non-Coding-PVT1 and c-MYC oncogenic signals
CircRNAs mechanisms of action. CircRNAs can act as miRNAs sponges inhibiting the silencing activity of miRNAs on their target genes and can also sponge proteins. They can interact with RNA binding proteins or with RNApol II and U1 splicing factor. They can undergo cap independent translation encoding small peptides. CircRNAs can be packaged into exosomes or can be involved in cell cycle regulation since they can act as scaffolding for proteins involved in cell cycle or can regulate autophagy process