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Fig. 2 | Molecular Cancer

Fig. 2

From: BCL-2 expression promotes immunosuppression in chronic lymphocytic leukemia by enhancing regulatory T cell differentiation and cytotoxic T cell exhaustion

Fig. 2

BCL-2 expression in CD4+ T cells is related to T cell activation, proliferation, and Tregs. (a) The Uniform Manifold Approximation and Projection (UMAP) plot of single cells obtained from six patients, representing 16 distinct clusters; cluster 6 stands for CD4+ T cells. Each dot corresponds to a single cell colored according to the cell clusters. (b) A volcano plot of differentially expressed genes (DEGs) to compare BCL2-positive and -negative CD4+ T cells. Each colored dot denotes an individual gene with an adjusted p value < 0.05. (c) Heatmap of DEGs compared between BCL2-positive and BCL2-negative CD4+ T cells. (d) GO enrichment analysis of DEGs. (e) Bar plot indicating Treg counts in BCL2-positive and -negative CD4+ T cells. (f) The dot plot of gene set enrichment analysis (GSEA) using helper T cell-related genes is indicated in the figure. (g–i) GSEA using IMMUNESIGDB, transcription factor target (TFT), and customized gene sets

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Molecular Cancer

ISSN: 1476-4598