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Fig. 4 | Molecular Cancer

Fig. 4

From: BCL-2 expression promotes immunosuppression in chronic lymphocytic leukemia by enhancing regulatory T cell differentiation and cytotoxic T cell exhaustion

Fig. 4

Distribution of different lineages of CD4+ T cells in BCL-2-positive and -negative CLL (n = 70). (a–e) Representative flow cytometry scatter plots of Th1 IFN-γ+, Th2 IL-4+, Th17 IL-17A+, Th22 IL-22+, and Tfh CD185+ cells in BCL-2+ and BCL-2− CD4+ T cells in patients with CLL. Percentage of cells positive for each part expression in CD4+ T cells of BCL-2-positive and -negative T cells is shown. (f) Representative examples of Tregs in CD4+BCL-2+ T and CD4+BCL-2− T cells in patients with CLL. Increased Treg frequency and absolute cell numbers in CD4+BCL-2+ T cells of patients with CLL are shown. Differences are shown in scatter plots (***p < 0.001, ****p < 0.0001)

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Molecular Cancer

ISSN: 1476-4598