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Fig. 3 | Molecular Cancer

Fig. 3

From: Current applications and future perspective of CRISPR/Cas9 gene editing in cancer

Fig. 3

The mechanism of base editing and prime editing. a A cytosine base editor (CBE) uses cytidine deaminase to bind to its homologous base to catalyze the deamination reaction and convert the cytosine in the R-loop to uracil. The resulting U•G base mismatch is then converted into T•A pair after DNA replication or repair. b Schematic of the adenine base editor (ABE). ABE-mediated deamination converts adenosine to inosine, which is subsequently read as guanosine during DNA replication. c Schematic diagram of the prime editor structure and prime editing mechanism

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