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Table 1 IHC analysis of ROR2 in patient samples. Tumor samples: P1 to P27 (cohort #1), P28 to P44 and controls 1 to 3 (cohort #2). The table indicates diagnosis, ALK status, the ALK fusion partner gene (when identified), percentage of tumor cells positive for ROR2, ROR2 staining intensity [from 0 (null) to 3 (high)] and cellular sublocalization of ROR2 (cyto = cytoplasm; membr = membrane). CT: common type, SC: small cell; LH: lymphohistiocytic; HL: Hodgkin-like; T-NOS: T lymphoma not otherwise specified, NA: non-applicable, CTL: Control samples

From: De novo generation of the NPM-ALK fusion recapitulates the pleiotropic phenotypes of ALK+ ALCL pathogenesis and reveals the ROR2 receptor as target for tumor cells

Cohort #1
PATIENTS (Fig. 6G) Diagnostic ALK ALK
partner
ROR2 intensity Percentage of tumoral cells expressing ROR2 (%) Localization
P1 ALCL CT pos NPM 3 100 Cyto
P2 ALCL CT + SC pos non NPM 1 80 Membr
P3 ALCL CT pos NPM 3 80 Cyto
P4 ALCL CT + SARC pos non NPM 3 100 Cyto
P5 ALCL CT pos NPM 3 100 Membr
P6 ALCL LH pos NPM 1 40 Cyto
P7 ALCL SC + CT pos NPM 2 100 Membr
P8 ALCL CT pos NPM 2 70 Cyto
P9 ALCL CT pos NPM 2 100 Cyto
P10 ALCL CT pos NPM 2 100 Membr
P11 ALCL CT pos NPM 3 100 Membr + Cyto
P12 ALCL HD + SC pos NPM 2 100 Membr
P13 ALCL CT pos NPM 1 100 Membr
P14 ALCL CT pos ALO17 2 100 Membr
P15 ALCL CT pos NPM 2 90 Cyto
P16 ALCL CT pos NPM 1 100 Cyto
P17 ALCL CT pos NPM 1 NA  
P18 ALCL SC + CT pos NPM 2 90 Membr
P19 ALCL SC pos NPM 1 50 Membr
P20 ALCL CT pos NPM 2 NA Cyto
P21 ALCL CT pos NPM 2 90 Membr + Cyto
P22 ALCL CT + SC + LH pos NPM 1 40 Cyto
P23 ALCL CT pos TFG 3 100 Cyto
P24 ALCL SC pos NPM 0 0 NA
P25 ALCL CT neg 0 0 0 NA
P26 ALCL CT neg 0 3 90 Cyto
P27 T-NOS neg 0 2 100  Membr + Cyto
Cohort #2
PATIENTS Diagnostic ALK ROR2 intensity Percentage of tumoral cells expressing ROR2 (%) Localization
P28 ALCL pos 3 100 Membr + Cyto
P29 ALCL pos 2 80 Membr
P30 ALCL pos 1 50 Membr
P31 ALCL pos 1to 2 90 Membr
P32 ALCL pos 2 100 Membr + Cyto
P33 ALCL pos 3 70 Membr + Cyto
P34 ALCL pos 3 80 Membr
P35 ALCL pos 1 to 3 100 Cyto
P36 ALCL pos 3 70 Membr + Cyto
P37 ALCL pos 3 80 Membr + Cyto
P38 ALCL pos 2 90 Membr + Cyto
P39 ALCL pos 3 100 Membr + Cyto
P40 ALCL pos 3 100 Membr + Cyto
P41 ALCL pos 2 100 Membr + Cyto
P42 Large cell NHL CD30+ neg 0 0 0
P43 ALCL neg 0 0 0
P44 ALCL neg 2 50 Membr
Control samples
CTL1 Non tumoral lymph nodes neg 0 0 0
CTL2 Non tumoral lymph nodes neg 0 0 0
CTL3 Nnon tumoral lymph nodes neg 0 0 0