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Fig. 3 | Molecular Cancer

Fig. 3

From: METTL14-mediated m6A modification of circORC5 suppresses gastric cancer progression by regulating miR-30c-2-3p/AKT1S1 axis

Fig. 3

METTL14 acted by m6A-dependent modification of circORC5. A MeRIP analysis of the effects of METTL14 knockdown on total m6A levels in MGC-803 and AGS cells. B, C Volcano plots and cluster mapping of the differential circRNAs in m6A levels by m6A-circRNA epitranscriptomic microarray. D MeRIP analysis of the m6A levels of circORC5, circ_0030632 an circ_0047481 in METTL14-knockdown MGC-803 and AGS cells. E RT-qPCR analysis of circORC5 expression in METTL14-knockdown MGC-803 and AGS cells. F Colony formation and G Transwell invasion assay were used to assess the effects of transfection with si-circORC5 and (or) si-METTL14 on cell proliferation and invasion in MGC-803 and AGS cells. Data are the means ± SEM of three experiments. *P < 0.05; **P < 0.01

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Molecular Cancer

ISSN: 1476-4598