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Fig. 4 | Molecular Cancer

Fig. 4

From: METTL14-mediated m6A modification of circORC5 suppresses gastric cancer progression by regulating miR-30c-2-3p/AKT1S1 axis

Fig. 4

Identification and characteristics of circORC5. A The genomic loci of the ORC5 gene and circORC5. B RT-qPCR analysis of circORC5 stability after exposure to treatment with RNase R exonuclease in MGC-803 and AGS cells. C RT-qPCR analysis of the cytoplasmic or nuclear location of circORC5 in MGC-803 and AGS cells. D FISH assessment of circORC5 localization in GC cells. E FISH analysis of the expression of circORC5 in 90 paired GC tissue samples. F Kaplan–Meier plotter of the association of circORC5 with overall survival in patient with GC. Data are the means ± SEM of three experiments. *P < 0.05; ***P < 0.001; ****P < 0.0001

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