Fig. 2
From: Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification
ALKBH5 inhibits cell invasion in vitro experiment (A-B) MRNA and protein level of ALKBH5 in HGC-27 cell with ALKBH5 overexpression. (C-D) MRNA and protein level of ALKBH5 in SGC-7901 cell with ALKBH5 knockdown. (E, G) Migration and invasion results of overexpressing ALKBH5 in HGC-27 cell, together with its statistical chart (scale bars = 200 µm). (F,H) Migration and invasion results of ALKBH5 knockdown in SGC-7901 cell, together with its statistical chart (scale bars = 200 µm). (I-J) wound-healing assay in HGC-27 and SGC-7901 cells (scale bars = 200 um). (K) Schematic diagram of ALKBH5 H204A. (L) M6A level of mRNA in NC, LV-ALKBH5 and ALKBH5 H204A group of HGC-27 cell. (M–N) MRNA and protein level of ALKBH5 in LV-ALKBH5 or H204A group of HGC-27 cell. (O-P) Migration and invasion results of wild-type ALKBH5 or ALKBH5 H204A in HGC-27 cell, together with its statistical chart (scale bars = 200 µm)