Fig. 6
From: Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification
ALKBH5-PKMYT1-IGF2BP3 axis inhibits invasion and migration in vivo experiment (A-D) Expression comparison of PKMYT1 and IGF2BP3 between metastasis-/ + and limph nodes metastasis-/ + group in TCGA dataset and TMA. (E–F) Survival analysis of ALKBH5, PKMYT1 expression and PKMYT1, IGF2BP3 expression group in TMA. (G-H) Representative live images and lung fluorescence statistics after tail vein injection with WT, LV-ALKBH5 and H204A GC cells. (I-J) Representative live images and lung fluorescence statistics after tail vein injection with NC and shRNA-1 GC cells. (K-L, O-P) HE staining of lung sections and statistical analysis on number of lung tumor nodules. (M–N, Q-R) Representative IHC pictures of ALKBH5 and PKMYT1 and their area density in lung sections