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Fig. 1 | Molecular Cancer

Fig. 1

From: CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells

Fig. 1

Downregulation of ABCB1 expression by ribociclib. A Molecular structure (3-dimentional) of ribociclib. B, C Immunofluorescence (IF) and Western blot data indicating ABCB1 expression was significantly downregulated by incubating the KB-C2 cells with 9 μM of ribociclib (Rib)/LEE011 for 72 h. Before the analysis, KB-C2 and KB-3-1 cells were incubated with 0.07 or 0.01 μM (lower than the IC50 values) of colchicine, respectively (to simulate the conditions with presence of colchicine during reversal of MDR and to maintain normal morphology in cells). ABCB1 expressed on the cell membrane is depicted by arrows in red

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