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Fig. 6 | Molecular Cancer

Fig. 6

From: CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells

Fig. 6

Flow cytometer analysis of cell apoptosis and cell cycle in KB-C2 cells with the deletion of cdk6 or cdk4 gene.A Apoptosis of KB-C2 cells with deletion of cdk6 or cdk4 gene. The KB-C2-k.o.cdk6 and KB-C2-k.o.cdk4 cells were either incubated with a vehicle (media without colchicine) or colchicine (Col) for 24 h. The fluorescent intensity of the cells at the various heights on the axis are presented as spot groups showing the percentage of viable to severely apoptotic cell populations. The populations comprising heavily apoptotic (HA) cells (P1-P6), moderately apoptotic (MA) cells, slightly apoptotic (SA) cells and non-apoptotic (NA) cells were indicated by dots in black, blue, green, and red, sequentially. Col: colchicine. The fluorescence of PI and FITC was determined through PC7-A and FITC-A tracks, respectively. B Alteration of cell cycle in the KB-C2 cells with the deletion of cdk6 or cdk4 gene. The cells were co-incubated with the vehicle or colchicine (Col) for 24 h. The fluorescence of PI was determined through PE-A track

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