Table 4 Representing the exosomal miRNAs in biological fluids as prognostic and diagnostic biomarkers and therapeutic targets in oral squamous cell carcinoma
From: Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer
Exosomal miRNA | Sample Type | Role | Mechanism of action | Reference |
|---|---|---|---|---|
miR-24-3p | Saliva | Diagnostic | inhibit OSCC cells from proliferating by targeting PER1 | He et al. (2020) [69] |
miR-130a | Plasma | Diagnostic and prognostic | predictive factor for overall survival and recurrence-free survival | He et al. (2021) [70] |
miR-155 and miR-21; miR-126 | Blood | Diagnostic and prognostic | suppress PTEN and Bcl-6 expression; tumor suppressor | Chen et al. (2021) [71] |
miR-34a-5p | Primary fibroblasts | Therapeutic target | enhanced nuclear translocation of β-catenin | Li et al. (2018) [72] |
miR-382-5p | Tissue and fibroblast cell | Therapeutic target | promotes the migration and invasion | Sun et al. (2019) [73] |
miR-30a | Serum | Therapeutic target | regaining sensitivity of the cisplatin-resistant | Kulkarni et al. (2020) [74] |
miR-130b-3p | Serum | Therapeutic target | Promotes Progression and Tubular Formation | Yan et al. (2021) [76] |