Fig. 2

Validation and performance evaluation of circRNA biomarker panel in clinical cohorts of tissue and serum specimens. A ROC curve analysis to evaluate the performance of 10 circRNAs based biomarker panel and B risk probability distribution plot in a pilot cohort of matched GC tissue specimens and adjacent normal mucosa (ANM). C ROC curve analysis to examine the performance of 8 circRNA-biomarker panel and D risk probability distribution plot in a training cohort of serum samples from GC patients and non-disease controls. E ROC curve analysis and F risk probability distribution plots in a serum validation cohort of serum samples from GC patients and non-disease controls. ROC curves are shown with 95% CIs. Green lines in right panel indicate 95% CIs of sensitivity and specificity for each circRNA; green points, best threshold for sensitivity and specificity