Fig. 4

Evaluation of the circRNA panel based on tumor histology, pre vs. post-surgery specimens and their expression in GC vs. other gastrointestinal cancers. A The diagnostic performance of biomarker panel according to tumor histology (diffuse and intestinal type) in both serum training and validation cohorts. B Expression of candidate circRNAs in pre- and post-surgery serum specimens from a prospective cohort of GC patients. C Assessment of risk probability based on risk prediction formula between pre-and post-surgery GC specimens. D Performance of liquid biopsy based circRNAs biomarker panel across different GI malignancies (gastric cancer, GC; colorectal cancer, CRC; pancreatic ductal adenocarcinoma, PDAC; esophageal squamous cell carcinoma, ESCC; hepatocellular cancer, HCC)