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Fig. 2 | Molecular Cancer

Fig. 2

From: Ferroptosis in cancer therapy: a novel approach to reversing drug resistance

Fig. 2

Reversing targeted therapy resistance by inducing ferroptosis. Activation of the downstream pathways of VEGFR, EGFR and PARP facilitates tumor survival and resistance to certain inhibitors (blue). Combination therapy with ferroptosis inducers (red) has been demonstrated to reverse targeted therapy resistance. VEGFR, vascular endothelial growth factor receptor; EGFR, epidermal growth factor receptor; PARP, poly (ADP-ribose) polymerase; xCT: cystine/glutamate antiporter; GSH: glutathione; GPX4: glutathione peroxidase 4; LIP: labile iron pool; ROS: reactive oxygen species; PLOH: phospholipid alcohols; PLOOH: phospholipid hydroperoxides

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