Fig. 3
From: Ferroptosis in cancer therapy: a novel approach to reversing drug resistance
Reversing immunotherapy resistance by inducing ferroptosis. There are two approaches to reversing immunotherapy resistance by inducing ferroptosis: a tumor cell-intrinsic approach that induces ferroptosis in cancer cells to elicit a vaccination-like effect to stimulate antitumor immunity and a tumor cell-extrinsic approach that triggers ferroptosis in the TME to deplete immune suppressor cells. TME, tumor microenvironment; PD-1: programmed cell death 1; PD-L1: programmed death-ligand 1; SAPE-OOH: 1-steaoryl-2-15-HpETE-sn-glycero-3-phosphatidylethanolamine; Tregs: regulatory T cells; TAMs: tumor-associated macrophages; IL-1β: interleukin-1β; Th17: T helper 17; DC: dendritic cell; ATP: adenosine triphosphate; HMGB1: high-mobility group box 1