Fig. 2

Effect of target silencing on different tumor types. A Effect of silencing by both CRISPR and RNAi on different cell lines from several tumor types. Data from DepMap portal. Common essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines. Strongly selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution. B CERES and DEMETER2 dependency score of each gene in the five tumors with the highest incidence including breast, lung, colorectal, prostate and gastric cancer. A score of 0 indicates that a gene is not essential, and a score of -1 is comparable to the median of all pan-essential genes